Restoration of Homeostasis During Histamine-Stimulated Gastric Secretion by Rapid Intravenous Injection of KCl
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The effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats
Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) needs to be investigated. Methods: For gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. A cannula ...
متن کاملEffect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion.
1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches the maximum secretory response to histamine (40 mug/kg i.m.) was augmented by i....
متن کاملHistamine dependence of pentagastrin-stimulated gastric acid secretion in rats.
Does gastrin stimulate gastric acid secretion by direct action on oxyntic cells, by releasing histamine, or by being potentiated by histamine? Previous studies in the mouse pointed to gastrin-regulated histamine release. Guinea pig and rat are well known to vary in their sensitivity to histamine. Therefore, the effects of histamine and pentagastrin were compared quantitatively on isolated, lume...
متن کاملIs pentagastrin-stimulated secretion mediated by histamine?
Patients with duodenal ulcer disease received either a two hour pentagastrin infusion test or a similar test with the addition of a bolus of cimetidine, 200 mg, after one hour of pentagastrin. Pentagastrin induced secretion of acid and histamine, the secretion patterns of the two being similar. Total histamine output in the gastric aspirate in the first hour of pentagastrin infusion was related...
متن کاملthe effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats
introduction: the protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (d2 dopamine agonist) on histamine stimulated gastric acid secretion (gas) needs to be investigated. methods: for gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. a cannula was ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1968
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(68)80162-3